Preparing Low Dose Naltrexone at Home

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Supplies Needed
•    50 mg tabs of naltrexone
•    5  ml syringe or graduated baby medicine dropper
•    4 oz amber glass jar with a tight fitting lid
•    Distilled water

Order your supply of 50mg Naltrexone tablets.  You can convert a 50mg tablet into low dose naltrexone (LDN) simply and easily. To do so, fill a graduated cylinder with 50 ml of distilled water (unlike tap or spring water, distilled water contains no impurities that could potentially react with and thus reduce Naltrexone’s effectiveness). You can also use whatever measuring device you have to measure out 50 ml.  Pour the water from the graduate cylinder into a 4oz glass jar; then drop in one 50mg tablet.  The tablet will mostly dissolve in about 2 hours.  Note that not all of the tablet is soluble in water so instead of yielding a clear solution, the result will be a cloudy suspension.  One ml of the (shaken) suspension will contain one mg of Naltrexone or another way of putting it is that you have created a 1 to 1 ratio of water and tablet. You can use a graduated baby medicine dropper or 5-ml syringe to measure out the dose you need.

Once a drug passes from a solid to a liquid state, its shelf life can decrease dramatically.  Therefore, do not make more than 50 ml of liquid Naltrexone at one time, store it in the refrigerator, and do not keep it for more than 2 months.  Be sure to shake the liquid LDN well before using and keep from direct exposure to sunlight.

The therapeutic dosage range for LDN is from 1.5mg to 4.5mg. Dosages below this range are likely to have no effect at all. Dr. Bahari prescribed doses of 1.5 to 4.5mg taken at bedtime. Bihari theorized that LDN causes a peak endorphin increase during the predawn hours. However, studies show that taking LDN at night is not necessary.

Bahari didn’t prescribe amounts greater than 4.5mg but he didn’t take body weight into consideration. Ian Zagon on the other hand recommends doses ranging from 3 – 10mg daily adjusted to the patient’s weight.
The most common approach in practice is to stop dose increases at 4.5mg.

You may want to gradually introduce the LDN to your system. Many patients start with 1.5 ml dose and continue with this dose for a week or two, then add 0.5 ml and continue for another couple of weeks, then increase again by 0.5ml, steadily increasing the dosage until you reach the maximum dosage which is 4.5 ml.

LDN has virtually no side effects. Occasionally, during the first week’s use of LDN, patients may complain of some difficulty sleeping or may experience vivid dreams. This rarely persists after the first week. Side effects are less likely to occur when a small starting dose is used and gradually increased. If you notice an increase in symptoms you may want to reduce the dose. If sleep disturbance is a problem Zagon recommends taking LDN in the morning.

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